What are Protein Interaction Networks?
Protein interaction networks (PIN) are a collection of proteins that depict the protein-protein interactions that occur within a cell. By characterizing the protein-protein interactions through PIN, a better understanding of how a specific protein plays a role in a bigger biological process can be established. [1]
What does the FOXE1 protein interact with?
Human Network
Cellular Component:
Mouse Network Cellular Component:
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Human and Mouse Protein Network Comparison
Discussion
The PIN of humans and mice are strikingly similar with identical proteins that are involved in thyroid gland development, embryonic organ morphogenesis, and endocrine system development. This further proves that mice are good model organisms for studying FOXE1's mechanism of action in thyroid morphogenesis.
References
[1] Vazquez A. Protein Interaction Networks. In: Alzate O, editor. Neuroproteomics. Boca Raton (FL): CRC Press/Taylor & Francis; 2010. Chapter 8. Available from: https://www.ncbi.nlm.nih.gov/books/NBK56024/
[1] Vazquez A. Protein Interaction Networks. In: Alzate O, editor. Neuroproteomics. Boca Raton (FL): CRC Press/Taylor & Francis; 2010. Chapter 8. Available from: https://www.ncbi.nlm.nih.gov/books/NBK56024/
Image References
[1] https://i1.wp.com/bioinformaticsreview.com/wp-content/uploads/2016/08/proteins.jpg?w=2040&ssl=1
[1] https://i1.wp.com/bioinformaticsreview.com/wp-content/uploads/2016/08/proteins.jpg?w=2040&ssl=1